MyTH: A new weekly series about one bacterial species. First Post: Escherichia coli « Taking Science to the People
This thought came to my head as I couldn’t sleep last night. My Tiny Highlight (MyTH) will be weekly and will showcase interesting or useful bacteria. For the first installment, I will focus on the gold standard of biology; Escherichia coli
or E. coli
. E. coli was discovered in 1885 by a German doctor in feces of healthy people. He called it Bacterium coli commune
because it was found in the colon. The classification system of bacteria was much different before the ability to sequence DNA as novel bacteria were initially classified and named by their shape and motility. The name later changed to Bacillus coli
before finally being reclassified and named Escherichia coli
after the original discoverer. How would you like it if someone named a bacteria from feces after you?
receives a bad reputation thanks to pathogenic strains that force recalls of all kinds of food products. However, those strains are very uncommon as E. coli
is one of the most abundant species found in the GI tract of mammals. Also, without this bacterium, many of the scientific discoveries of the past 50 years would not be possible including solving protein 3D structures, mass production of insulin, and understandingsignal transduction
; the process of a cell sensing surrounding signals or cues and responding to them in a way that is favorable for the cell. One reason E. coli
was such a well suited model organism is the doubling time
or time to divide one cell into two daughter cells. A doubling time of only 20 minutes means in less than 48 hours, the mass of E. coli
cells would roughly be equal the the mass of Earth and have the combined volume equalling a 1 meter thick layer of bacteria covering the entire surface of Earth (including oceans). This is incredible and gives E. coli
a major advantage over slower growing bacteria.
I want to discuss, briefly, a major influence of mine. Julius Adler
was born in Germany and became a lover of Nature as a child. He was fascinated with butterflies.
His lifelong passion has been behavior of living things. Luckily, he spent most of his professional career studying chemotaxis
in E. coli
although he now studies fruit flies. Adler is known as the father of chemotaxis, or the movement of a cell in response to sensing chemical signals. His landmark early papers in the journal Nature
about chemotaxis in E. coli
in 1966 and his later paper on the chemoreceptors, the proteins that interact with the surrounding chemicals, in E. coli
laid the foundation that maid the chemotaxis system of E. coli
the best characterized signaling pathway in Biology. In regards to chemotaxis, however, E. coli
is on the simplistic side of the scale. For example, E. coli
has 5 chemoreceptors and 1 chemotaxis operon, or a stretch of genes that are transcribed into RNA
together but lead to distinctly different proteins that usually interact with each other. Through the explosion of genome sequencing, scientists can scan newly sequenced bacteria genomes for chemotaxis genes. The average number of chemoreceptor genes is roughly 5 times more than E. coli
(~25) and it is more common for bacteria to harbor multiple chemotaxis operons suggesting most bacteria have evolved to use chemotaxis for regulate more than the motility behavior in these cells.
Let’s think a minute about why E. coli is ‘stupid’ compared to other bacteria. By ‘stupid’ I mean, they have less capacity to integrate signals from their surroundings into a cell response. Why doesn’t E. coli have 25 chemoreceptors, for example? For the answer, we just need look at where this microbe is found. The GI tract of mammals is fairly constant meaning there is less need to scavenge for a new home or adjust to changes in temperature or nutrients. We as mammals have no problems eating meaning E. coli has no problem eating as well. How about the other sequenced bacteria? They predominantly live in more variable environments like soil or oceans where is would be to their advantage to be able to sense a lot of chemicals or nutrients in their surroundings. Therefore, through evolution, they have acquired new abilities to sense through duplicating genes and mutating DNA favorably. Changing only a few nucleotide bases (A,C,G,T) could mean acquiring the ability to physically interact with different environmental chemicals that could serve as an energy source. Nature is awesome and she knows how to keep us, as observers, guessing.
You may feel I am biased about chemotaxis ( I am). This was my dissertation work in another bacterium. Check back next week when I will highlight a little known (publicly) soil bacterium, Azospirillum brasilense. If you have any comments, questions, or suggestions PLEASE LET ME KNOW!